Abstract: The current difficulties in the diagnosis and treatment of Fungal keratitis (FK) are not easily detected in early diagnosis of the disease, the biotoxicity of antifungal drugs and the low bioavailability of the drugs in the eye, etc. With more research on FK treatment in recent years, new drugs and drug carrier formulations have been proposed and their efficacy has been verified in animal models of FK infection. Regarding surgical treatment, corneal transplantation, and photodynamic therapy are the more commonly used treatment modalities, while the newly proposed low-temperature plasma surgical system is more advantageous in the control of infection and safety in the treatment of FK. (Int Rev Ophthalmol, 2023, 47: 360-366)

Key words: fungal keratitis, drug therapy